Synergy Pharmaceuticals
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for constipation

Novel therapeutics from breakthrough research

in gastrointestinal disorders and diseases    

Synergy Pharmaceuticals, Inc. (NASDAQ:SGYPD) is a public, development-stage biopharmaceutical company that develops drugs to treat gastrointestinal (GI) conditions and diseases. 

Our patented drug candidates, currently in clinical development, were discovered and developed in-house by Synergy scientists.

The company has its headquarters in New York City and also operates a research laboratory in Doylestown, PA that supports Synergy’s drug development programs.

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for constipation
for constipation
chronic constipation

Synergy’s drug development program and patent estate are based on a class of synthetic peptides designed to mimic uroguanylin, a human hormone that regulates intestinal fluid transport.

Synergy has a lead drug, Plecanatide, in clinical development to treat chronic constipation (CC) and constipation-predominant irritable bowel syndrome (IBS-C). A second drug, SP-333, is in pre-clinical development for GI diseases.

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GI diseases

Lead Drug Development Program: Plecanatide

chronic constipation
Synergy is a biopharmaceutical company focused on the development of new drugs to treat gastrointestinal disorders and diseases. Synergy's lead proprietary drug candidate plecanatide is a synthetic analog of the human gastrointestinal hormone uroguanylin, and functions by activating the guanylate cyclase C receptor on epithelial cells of the GI tract. The company completed a Phase I study in healthy volunteers and a Phase IIa clinical trial in CIC patients. Plecanatide is also being developed to treat constipation-predominant irritable bowel syndrome, with the first trial in IBS-C patients planned for 2012. Synergy’s second GC-C agonist SP-333 is currently in pre-clinical development to treat inflammatory bowel diseases. More information is available at http://www.synergypharma.com.

The market opportunity for gastrointestinal therapeutics was recently valued at around $50 BN in 2008. The US market which comprises almost 40% of the estimated global market is worth almost $19 BN.

Chronic constipation and IBS-C have a wide prevalence, affecting up to 15% and 20% of the population respectively. More than 100 million people worldwide suffer from these conditions.

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Gastrointestinal Disorders (GI)  & Diseases

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Plecanatide is a member of a new class of essentially non-systemic drugs, referred to as guanylate cyclase C (GC-C) agonists, that are currently in development to treat CIC and IBS-C, which includes a first-in-class drug being developed by Ironwood (Nasdaq: IRWD) and Forest Labs (NYSE: FRX). Plecanatide is a synthetic analog of uroguanylin, a natriuretic hormone that regulates ion and fluid transport in the GI tract.
Plecanatide is a member of a new class of essentially non-systemic drugs, referred to as guanylate cyclase C (GC-C) agonists, that are currently in development to treat CIC and IBS-C, which includes a first-in-class drug being developed by Ironwood (Nasdaq: IRWD) and Forest Labs (NYSE: FRX). Plecanatide is a synthetic analog of uroguanylin, a natriuretic hormone that regulates ion and fluid transport in the GI tract.
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Synergy News Highlights

Plecanatide is a member of a new class of essentially non-systemic drugs, referred to as guanylate cyclase C (GC-C) agonists, that are currently in development to treat CIC and IBS-C, which includes a first-in-class drug being developed by Ironwood (Nasdaq: IRWD) and Forest Labs (NYSE: FRX). Plecanatide is a synthetic analog of uroguanylin, a natriuretic hormone that regulates ion and fluid transport in the GI tract.
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8 Feb 2012 Synergy Pharmaceuticals Engages The Trout Group for Investor Relations Services

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4 Jan 2012 European Patent Office Upholds Synergy Pharmaceuticals’ Grant of Claims to Plecanatide

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13 Dec 2011 Synergy Pharmaceuticals Announces Full Exercise of Over-Allotment Option by Aegis Capital Corp.

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13 Dec 2011 Synergy Pharmaceuticals, Inc. Files Suit Against Ironwood Pharmaceuticals, Inc. and its Chief Scientific Officer and Senior VP of R&D, Dr. Mark G. Currie

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6 Dec 2011 Synergy Pharmaceuticals Announces Closing of Public Offering of 1,875,000 Units

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